Phenotypes de resistance a 4 antibiotiques des germes isoles dans une formation hospitaliere

ABSTRACT

The sensitivity of bacterial strains isolated during the last semester of 1979 at the Military hospital d'lnstruction Mohammed V is studied using the method of gelose diffusion and three antibiotics amino glycosides l'Amikacine, Gentamicine and Tobramycin] and a semi synthetic penicillin [Ampicillin]. The authors studied 995 strains isolated from different suppurations [103 blood cultures 423 urine cultures and 469 abceses of diverse origin]. Amikacin was very active against most of the strains [921 or 92,6%]. The analytic study showed that - for gram negative strains Amikacine was more effective than the other two aminoglycosides and Ampicilline [only 51,3% of the strains for this latter]. - the phenotypes of resistance were of this type Amikacine + Gentarnicine, Amikacin + Tobramycin and Gentamicin + Tobramycin with a net predominance of this latter in the strains isolated from abseses. - Against the staphylocossus aureus the three aminoglycosides had almost the same activity with a small edge to Amikacin [93, 5%]. On the opposite there was a marked resistance against Ampicillin [42,7% only of sensitive strains]. There was no Amikacin Gentamicin phenotype of resistance. Finally other strains were tested salmonella [40] and pseudomonas aeroginosa [75], Amikacin was the most sensitive against salmonella [35 strains] and Gentamicin against pseudomonas [63 sensitives strains]