Seroprevalance of helicobacter pylori among Egyptian pastients with hepatic encephalopathy

ABSTRACT

Hepatic encephalopathy is a serious complication of end stage liver disease [ESLD], several theories for etiopathogenesis have been suggested, recently Helicobacter pylon [H. pylon] have been hypothesized to be correlated with the severity of hepatic encephaloptahy. Is to assess for the prevalence of H. pylon in patients with hepatic encephalopathy and to study its correlation with severity of illness. 75 patients with ESLD were evaluated; 50 patients with hepatic encephalopathy and 25 patients without encephalopathy. In addition to 25 healthy subjects served as a control. Demographic data of studied patients were collected and staging of encephalopathy was done according to West Haven classification system. Seropevalence of H. pylon was evaluated by ELISA. Seroprevalence of H. pylon infection was 74% in encephalopathy group while it was 64% and 44% in patients without encephalopthy and healthy subjects respectively. Prevalence and titre of H. pylon were found significantly increasing with the severity of hepatic encephalopathy. There is a significant association between FT. pylon and patients of liver disease with hepatic encephalopathy. There may be a role of anti-H. Pylon therapy in patients of hepatic encephalopathy and should be investigated further