Anti-cyclic citrullinated peptide antibodies as a discriminating marker between rheumatoid arthritis and chronic hepatitis C-related polyarthropathy
Medical Journal of Cairo University [The]. 2008; 76 (3 Supp. I): 137-141
em Inglês
| IMEMR
| ID: emr-101446
ABSTRACT
Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult especially with recent onset RA before articular damage and erosions develop. To assess the diagnostic utility of anti-CCP antibodies and compare it with that of rheumatoid factor in distinguishing between rheumatoid arthritis and HCV related polyarthropathy. Anti-CCP antibodies and RF were determined in the sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy. Anti-CCP antibodies were positive in 83.3% of patients with RA and in 4.5% in patients with HCV and polyarthropathy. RF was positive in 90% of RA patients and in 81.1% of HCV patients with polyarthropathy. The anti-CCP antibodies showed higher specificity for RA compared to RF [95.4% Vs 18.2%]. However the sensitivity of anti-CCP was comparable to that of RF [83.3% Vs 90%]. Anti-CCP antibodies are reliable laboratory markers to differentiate between RA and HCV-related polyarthropathy
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Peptídeos Cíclicos
/
Artrite
/
Fator Reumatoide
/
Sedimentação Sanguínea
/
Biomarcadores
/
Hepatite C Crônica
/
Testes de Função Hepática
/
Anticorpos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Cairo Univ.
Ano de publicação:
2008
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