Can we use serum interleulkin -1 beta in diagnosis of early neonatal sepsis?

ABSTRACT

Neonatal sepsis is an important cause of morbidity end mortality with a predictably poor outcome unless early diagnosis and appropriate treatment serum interleukin -1 beta can be used to diagnose early neonatal sepsis. serum samples of interlukin -1 beta of 80 neonates 20 FT healthy and 20 PT as control 20 FT septic and 20 preterm septic the study is to evaluate specificity and sensitivity of that test to predict neonates with early sepsis. All cases were admitted to NICU and Nursery in Ahmed Maher Teaching Hospital. No significant difference in serum interleuk in 1-beta in comparing the diseased FT group and the control FT group. While there was significant increase in serum interleukin 1-beta in septic preterun group. As well as there was significant correlation between serum level IL-1 beta and maternal infection as a maternal risk factor. Seurm level of interleukin-1-beta can aid in laboratory diagnosis of early sepsis in preterm neonates but not of value in early sepsis of FT ones