Oxidative stress in first degree relatives of type 2 diabetic patients
International Journal of Diabetes and Metabolism. 2009; 17 (1): 17-19
em Inglês
| IMEMR
| ID: emr-101927
ABSTRACT
Epidemiological studies on twins and families have provided a strong correlation for genetic factors contributing to etiology of type 2 diabetes mellitus [T2DM]. Diabetes mellitus is strongly associated with oxidative stress, which can be a consequence of either increased production of free radicals, reduced antioxidant defense or both. The present work was undertaken to study known markers of erythrocyte oxidative stress malondialdehyde [MDA] and reduced glutathione [GSH] in first degree relatives of T2DM patients, and plasma antioxidant status in an effort to understand the role of oxidative stress in the etiology of type 2 diabetes. Our results show that the antioxidant potential of the plasma is 14% lower in first degree relatives, the intracellular GSH is lower by 9% and lipid peroxidation measured in terms of MDA is elevated by 20%, compared to normal controls. These findings show that an impaired redox balance may be a cause for disturbance of homeostasis in type 2 diabetic families even before the development of the disease. We hypothesize that that oxidative stress precedes the development of overt diabetic state
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Família
/
Diabetes Mellitus Tipo 2
/
Eritrócitos
/
Glutationa
/
Malondialdeído
Limite:
Humanos
Idioma:
Inglês
Revista:
Int. J. Diabetes Metab.
Ano de publicação:
2009
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