Quantitative changes in serum IL-8, TNF-alpha and TGF-beta[1] levels depending on compensation stage in type 2 diabetic patients

ABSTRACT

To evaluate serum levels of cytokines, IL-8, TNF-alpha and TGF- beta[1], as well as HbA1c, total protein, albumin, urea, creatinine, IgG, IgA, IgM according to compensation stages in type 2 diabetic patients. All patients [n = 76], depending on the level of glycemia and disease duration were divided into 3 groups in the stage of compensation [n=28], subcompensation [n=20] and decompensation [n=28]. Cytokines were measured by ELISA method. Control group included healthy subjects. Cytokine values increased in all three stages of the disease, especially in the stage of decompensation in comparison with control subjects. IL-8, TNF-alpha and TGF-beta[1] may participate in the development and progression of diabetic complications. Further study of these immune dates may open new perspective opportunities in prevention and treatment of late complications of diabetes