Effect of ethanol extract of flowers of Vitex Trifolia Linn. on CCL[4] induced hepatic injury in rats
Pakistan Journal of Pharmaceutical Sciences. 2009; 22 (4): 391-394
em Inglês
| IMEMR
| ID: emr-102260
ABSTRACT
Hepatoprotective activity of ethanolic extract of flowers of Vitex trifolia [Verbenaceae] was studied against CCl[4] induced hepatic injury in albino rats. The plant extract [EVT] at the dose of 200 mg/kg, p.o. showed a remarkable hepatoprotective activity. CCl[4] induced a significant rise in serum glutamate pyruvate transaminase [SGPT], serum glutamate oxaloacetate transaminase [SGOT], alkaline phosphatase [ALP], total bilirubin and gamma glutamate transpeptidase [GGTP]. Treatment of rats with EVT significantly [P<0.001] altered serum biomarker enzyme levels to near normal against CCl[4] treated rats. The activity of the extract was comparable to the standard drug, silymarin [100 mg/kg, p.o.]. Histopathological observations also revealed that treatment with EVT protected the animals from CCl[4] induced liver damage. The results indicate that the flowers of V. trifolia possess hepatoprotective activity on CCl[4] induced hepatic injury in rats
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Tamanho do Órgão
/
Plantas Medicinais
/
Solventes
/
Intoxicação por Tetracloreto de Carbono
/
Ratos Wistar
/
Flores
/
Etanol
/
Doença Hepática Induzida por Substâncias e Drogas
/
Testes de Função Hepática
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2009
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