Local anti-inflammatory and anti-nociceptive activities of coldenia procumbens linn.

ABSTRACT

The ethanolic extract of the leaves of Coldenia procumbens Linn, was studied in Swiss albino mice against 12-O-tetradecanoylphorbol-13-acetate [TPA] and arachidonic acid [AA] induced inflammatory response, while the analgesic effect was studied using the acetic acid-induced writhing in mice and formalin-induced nociception. The ethanolic extract produced dose dependent anti-inflammatory activity against the pathogens. It also showed an inhibitory effect on pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The results indicated that the ethanolic extract produced significant [P<0.05] anti-inflammatory and anti-nociceptive activity when compared with the standard and untreated control