Role of serum estradiol and progesterone in the regulation of male fertility

ABSTRACT

In the present study, serum estradiol and progesterone concentrations were determined in men representing infertile couples. Data were analyzed using analysis of variance [ANOVA], Tukey multiple comparison tests and Student's t-test with regard to estradiol, normal, low and high concentrations were observed. Mean serum concentrations of E2 [pg/ml] in the three groups were 28.25 +/- 2.13, 3.14 +/- 1.23 and 82.62 +/- 19.3 pg/ml respectively. The serum concentrations of E2 were significantly different [p<0.0001], whereas mean age did not differ significantly [p>0.05] among the groups. Space of serum progesterone levels, both normal [<0.3 ng/ml] as well as elevated cases were seen. The mean serum concentrations of progesterone in the groups were 0.039 +/- 0.018 ng/ml and 0.93 +/- 0.39 ng/ml respectively. There was a significant difference [p<0.002] between the groups with respect to mean serum concentration of progesterone. However, mean age was not significantly different [p>0.05] between the groups. It can be concluded that endocrine screening of men with estradiol may detect the vast majority of clinically significant endocrinopathies