Perivascular epithelioid cell tumor [PEComa] of the uterus with aggressive behavior at presentation
Hematology, Oncology and Stem Cell Therapy. 2009; 2 (3): 426-430
em Inglês
| IMEMR
| ID: emr-102598
ABSTRACT
Perivascular epithelioid cell tumor [PEComa] is a rare mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells [PECs]. Both benign and malignant tumors have been identified, but the criteria for diagnosis of malignancy have not been fully established due to the rarity of the tumor. We report on a case of uterine PEComa in a 33-year old woman with lymph node metastasis at presentation. The tumor had the characteristic histologic features of PEComa with cytologic atypia, mitotic activity of 2/10 high power field [HPF], and necrosis; it exhibited immunopositivity for HMB-45, calponin and desmin and was negative for melan-A. The patient received neoadjuvant chemotherapy, debulking surgery and adjuvant chemotherapy. No evidence of recurrence or metastasis was apparent 8 months after surgery
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Neoplasias Uterinas
/
Quimioterapia Adjuvante
/
Neoplasias de Células Epitelioides Perivasculares
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Hematol. Oncol. Stem Cell Ther.
Ano de publicação:
2009
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