Triple hepatitis: frequency and treatment outcome of co/super-infection of hepatitis C and D among patients of hepatitis B
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2008; 18 (7): 404-407
em Inglês
| IMEMR
| ID: emr-102878
ABSTRACT
To determine the frequency of hepatitis C and D in patients of chronic hepatitis B and the treatment response of hepatitis B in such patients. Case series. Civil Hospital and Lyari General Hospital, Dow University of Health Sciences, from July 2003 to June 2005. All patients of hepatitis B presenting during the study period were screened for triple infection by carrying out anti-HBc [IgG], anti-HCV and anti-HDV. Patients who were positive to all three were included in the study. Complete Blood Count [CBC]; HBsAg; HBeAg; anti-HBc IgM; anti-HDV; anti-HCV; HBV DNA PCR; HCV RNA PCR; serum albumin; SGPT; serum bilirubin and ultrasound abdomen were acquired in all patients. All patients received pegylated interferon-alpha 2a 180 mcg sc weekly x 48 weeks. Patients who were also positive for HCV RNA also received ribavirin 1000-1200 mg/d po x 24 weeks for genotype 3 and 48 weeks for genotype 1. Descriptive statistics were used for describing the data. Out of the 246 patients of HBV, 29 [11.8%] patients were also positive for anti-HBc IgG, anti-HDV and anti-HCV. After 48 weeks of therapy, the respective viral undetection by PCR was 4 [13.8%] in patients having only HBV DNA, 3 [10.3%] in patients with only HCV RNA and in patients who had both HBV DNA and HCV RNA positive, simultaneously HCV was cleared in 2 [6.9%] while HBV was not cleared in any case. In patients coming with one hepatic infection, other infections should be sought as they share a common mode of spread and may affect the overall response to treatment
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ribavirina
/
Hepatite D
/
Estudos de Coortes
/
Interferons
/
Resultado do Tratamento
/
Hepatite C
/
Gerenciamento Clínico
/
Hepatite B Crônica
Tipo de estudo:
Estudo de incidência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Coll. Physicians Surg. Pak.
Ano de publicação:
2008
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