Risk of development of chronic kidney disease in patients with type 2 diabetes having metabolic syndrome
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2008; 18 (8): 472-476
em Inglês
| IMEMR
| ID: emr-102920
ABSTRACT
To measure the relation of creatinine clearance in type-2 diabetic patients with different components of metabolic syndrome and to quantify the relationship of frequency of incident CKD with increasing number of metabolic syndrome components while controlling for age, gender and duration of diabetes. Cross-sectional descriptive study. Diabetes Clinic, Fauji Foundation Hospital, Rawalpindi, from January to August 2006. Patients having type-2 Diabetes for more than 5 years were enrolled. Information regarding age, gender, duration of diabetes, type of diabetes, treatment taking, complete fasting lipid profile, fasting blood glucose, Body Mass Index [BMI], 24 hours urinary proteins and creatinine clearance, co-existent risk factors like hypertension and ischemic heart disease was taken. Patients were divided into groups having one to all five metabolic syndrome traits. Progressive increase in the metabolic syndrome traits was compared with decline in creatinine clearance. Pearson correlation test and multiple logistic regression were applied to determine correlation with significance at 'r' and 'p' = 0.05. Out of 104 evaluated female and male patients, 70% had hypertension, ischemic heart disease and a family history of diabetes. While 20% had normal creatinine clearance, 37% had a creatinine clearance between 60-90 ml/min, 19% had a creatinine clearance of 30-59 ml/min, 18% had a creatinine clearance of less than 30 ml/min and 10% were already in stage 5 CKD. The decline in renal function was more severe in subjects evaluated who had a higher number of features of the metabolic syndrome. Age was the only significant determinant of development of CKD [p=0.05]. The renal function progressively declined with 3 or more features of the metabolic syndrome
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Glicemia
/
Doença Crônica
/
Estudos Transversais
/
Fatores de Risco
/
Isquemia Miocárdica
/
Medição de Risco
/
Creatinina
/
Síndrome Metabólica
/
Diabetes Mellitus Tipo 2
/
Dislipidemias
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Coll. Physicians Surg. Pak.
Ano de publicação:
2008
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