[Reversibility of physical and psychological stress effects on contractility of isolated aorta and serum corticosterone levels one month after stress in rat]

ABSTRACT

Although data shows the effects of stress on the cardiovascular system, there is no information on their reversibility. The aim of this study is to determine the reversibility of stress effects on resposiveness of isolated rat aorta. Thirty-six male rats were divided into three groups, the control, physical stress, and psychological stress groups. During study animals were kept in 12h/12h light/dark cycles at 23 +/- 2 °C and had free access to food and water. Stress was induced by the Communication Box for three weeks. Physical stress applied with electrical current [1mA, 1hz, 10 sec/min] applied one hour twice daily. After one month recovery post stress responsiveness of isolated aorta to potassium chloride and phenylephrine were determined. The results of this study showed that one month recovery, following stress reverse, serum corticosterone and isolated aortic contractility in rats, so that no significant differences were observed between the control and stress groups; the decreased adrenal weight coused by physical stress also reversed to normal one month after stopping the stress. It can be concluded that effects of physical and psychological stress on isolated aortic tensions is not permanent, and can be reversed