[ effect of isotretinoin on plasma homocysteine concentration of patients with acne vulgaris]

ABSTRACT

Isotretinoin [ISO] revolutionized the treatment of acne since 1980s and there after, severe forms of acne have been treated more effectively, with less residual cosmetic or psychological damage. The use of Isotretinoin is associated with significant side-effects such as mucocutaneous involvement, dyslipidemia and increased liver enzymes. The aim of study was the evaluation of homocysteine [Hey] levels and the responsible vitamins for its metabolism in patients with moderate to severe acne vulgaris undergone ISO treatment. Forty-seven [n=47] patients with acne, prepared with liver function tests, folate, vitamin B12, homocysteine and serum lipids evaluations. Hey was evaluated before [Value 1] and on the 2[nd] month [value 2] of treatment with Isotretinoin [0.5 mg/kg/day], by HPLC methods. Hey levels [value 1 11.8 +/- 5.3 micro mol/L vs. value 2 13.6 +/- 7.4 micro mol/L; P<0.001] were statically significantly increased in patients treated with ISO. In addition, lipids and liver enzymes increased in mentioned group. However, there was no significant correlation between Hey levels, vitamins and liver enzymes. Elevated Hey levels in patients after 2 months on ISO treatment might be resulted from liver function disturbances. Folate supplementation along with frequent evaluations of Hey serum levels are strongly reconnnened for the prevention of a premature occlusive disease