Effect of nystatin, gentian violet and garlic extract on candidiasis patients undergoing radiation therapy in head and neck region

ABSTRACT

To evaluate the in-vivo anticandidal activity of Nystatin, Gentian Violet and Garlic extract on candidiasis patient receiving radiation therapy in Head and Neck region. The in-vivo antifungal activity of Nystatin, Gentian Violet and Garlic Extract were carried out on 60 patients. These patients were divided into 3 groups [Group I = Nystatin, Group 2= Gentian violet, Group 3= Garlic extract]. Each group consisted of 20 patients. The clinical lesion were recorded and graded during the treatment according to the Lindquist/Hickey scale on 0th 7th and 15th day and the anticandidal effect of these drugs were evaluated by oral lesion index evolution through simple mean. Result showed that Nystatin, Gentian violet and Garlic Extract were found to be very effective. It can be concluded from the study that all the drugs were effective against Candida albicans and secondly the organism has not developed any resistance to these drugs