Correlation between clinical presentation and genotypes of human giardiasis

ABSTRACT

The aim was to study the genotypes of human giardiasis and its relation to the symptoms of the clinical presentation. 105 patients. with giardiasis In the stool, 61 were symptomatizing and 44 were asymptomatic. and 20 subjects serving as a control group with negative stool examination for giradiasis. all were examined by PCR of stool to detect genotypes of G.L. PCR detected G.L. in 73.3% and failed to detect G.L in 26.7% of cases with G.L. in stool, and was negative in all control subjects. this mean. RCR specificity is 100% and sensitivity 73.3% for G.L. Three genotypes were detected, genotypes I in 36.19%. genotype II in 12.38% and genotype III in 9.52%, and mixed genotypes were detected in 15%, of cases with G.L In the symptomatic patients genotype I was 32.79%, genotype II was 16.39% and genotype III was 9.64%, mixed genotypes infection in 16.39% and undetermined genotypes was 24.59% while in the asymptomatic group. genotype I detected in 40.91% genotype II In 6.82%. genotype II in 9.59% mixed genotypes in 13.64% and undetermined in 29.55%. There was no statistically significant difference between symptomatic and asymptomatic group regarding G.L genotype distribution and the genotype of G.L was not related to symptoms of clinical presentation. the study revealed genetic diversity of G. Lamblia infection in the studied population and the genotypes of G. Lamblia were not related to the symptoms of clinical presentations