Medical Journal of Islamic World Academy of Sciences. 2010; 18 (1): 5-8
em Inglês
| IMEMR
| ID: emr-105826
ABSTRACT
The purpose of the study was to determine whether reduction of serum levels of bilirubin is more in full-term newborn with non-hemolytic hvperbilirubinemia that treated with new treatment than in matched control subjects. Eighty consecutively admitted term health neonate with indirect hvperbilirubinemia and indication for phototherapy were randomized into receiving phenobarbital [3 mg/kg/day] plus phototherapy as new treatment method or phototherapy as routine method after obtaining intformed consent. The neonate followed up until discharge. The total serum bilirubin levels were measured four times a day. Patient's data regarding variation of bilirubin and hospitalization duration collected and compared from the two groups. Results are presented as the mean, 95% confidence interval, 0.05% significance level and 80% power The baseline characteristics were similar in two groups. Mean ages were 5.5 +/- 2.81 and 4.80 +/- 1.68 days for control and case group respectively. Mean bilirubin levels in admission were l 9.48 +/- 2.80 mg/dl and 18.51 +/- 166 for control and case group respectively. There was significant reduction of bilirubin levels in case group compared to control group [10.54 +/- 3.00 mg/dl versus 8.60 +/- 1.99 mg/dl] [P=0.001]. No significant difference with respect to duration of hospitalization was observed in two groups' [2.05 +/- 0.59 days for control versus, 2.15 +/- 0.80 days for case group]. In despite of significant reduction of bilirubin levels in case group compared to control group, combined treatment is not helpful in reducing of hospitalization days of non-hemolytic hyperbilirubinemia in healthy term neonates
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Fenobarbital
/
Fototerapia
/
Bilirrubina
/
Recém-Nascido
/
Distribuição Aleatória
/
Hiperbilirrubinemia Hereditária
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Islamic World Acad. Sci.
Ano de publicação:
2010
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