Leucoctye acid phosphatase in haematologic disroders

ABSTRACT

Variations in the level of scores and reaction patterns of the acid phosphatase [APh] activity were estimated in blood films of 60 patients with various hematologic disorders and 30 normal controls using the azo-dye method of Goldberg and Barka [1962] with some modifications. The percentage of lymphocytes showing dot-like APh. Positivity was high in disseminated lymphoblastic lymphoma [T cell pattern], but low in acute and chronic lymphatic leukaemia [Non T pattern]. These findings are considered an additional proof to the validity of APh. As a cytochemical marker for the recognition of T-lymphocytes in malignant lymphoproliferative disorders. Also, our study showed that APh. May be helpful in the detection of remission in malignant lymphoma. Neutrophil APh. Activity is increased in malignant lympho-proliferative disorders, myeloproliferative disease, bacterial infection and leukaemoid reaction