electrical behaviour of an excitable cell at different conditions

ABSTRACT

The Hodgkin-Huxley, H-H model has been modified in this work to study the electrical behavior of an excitable cell due to changes in the permeability of K and Na ions [9K and 9Na], the simultaneous stochastic variations of gK and 9Na, the current stimulus [Jstim] and the non-inactivation of Na-channel [NI-NaC]. The amplitude and duration of the generated action potential [AP] was found to increase as 9K increase, with the appearance of repetitive AP spikes in the range of 21.5 >/= 9K >/= 3.5, while the K- and Na-currents [JK and JNa] showed a pronounced decrease. On the other hand, the increase of 9Na was accompanied by an increase in AP amplitudes and durations and also in JK and JNa with the appearance of a repetitive AP at 1400 >/= 9Na >/= 189 m/cm2, whose frequency increases with the increase of 9Na. Moreover, the stochastic variations in 9K and 9Na could generate a repetitive AP whose frequency could be changed either by changing the values of 9K or 9Na or both, and may represent an information carried by the sensory cells for example. The electrical behavior of the stimulated cell can also be affected by Jstim at different values of 9K except at the range of 21.5 >/= 9K >/= 3.5 m/cm2 and also depended on NI- NaC fraction