Combined modality approach of locally advanced breast cancer with conservative surgery

ABSTRACT

One hundred and eleven patients with noninflammatory locally advanced breast cancer [LABC] stage IIIA and B [T3-4b, No-2] were treated. Patients were randomized into two groups The study group A [61 patients] and the control group B [50 patients]. Patients of group A received three cycles [FAC] neoadjuvant chemotherapy [NCT] [5- fluorouracil 500 mg/m2, adriamycin 50 mg/m2 and cyclophosphamide 500 mg/m2, every three weeks]. Lumpectomy and axillary dissection [LAD] were performed for patients achieving downstaging to /tumor bed by iridium-192 [Ir-192] or electron beam [EB] [15-20 Gy]. Those whose tumor was still >T2 after NCT and El underwent simple mastectomy and axillary dissection [SM + A]. All patients of group A received 5 cycles adjuvant [FAC] and in addition tamoxifen [20 mg/day] was given to postmenopausal. It was concluded that multimodality treatment utilizing NCT, El and conservative surgery [CS] can give results comparable to conventional modalities of treatment