Comparative analysis of the phagocytic power and immunoglobulin status in hemopoietic malignancies and solid tumors

ABSTRACT

This study was carried out to evaluate the phagocytic activity of neutrophils and immunoglobulins among patients with ALL, lymphomas and some solid tumors. This study involved 107 patients who presented to National Cancer Institute [ALL, NHL, solid tumors and normal controls]. All patient groups showed a statistically significant decrease of phagocytic power of neutrophils in comparison to control group, pre and post-treatment. Also, solid tumors showed significantly lower post-treatment than pre-treatment levels. The NBT test showed lower levels in remission as compared to pre- treatment ones in all groups except in ALL, where it showed higher levels in remission. In ALL, there was a significant decrease in IgA level [pre and post treatment] than controls. There was a significant increase of IgM levels in patients with HD in remission than pre- treatment levels. In solid tumors, pre-treatment Ig status showed significant increase in IgM level. Lymphoma group [HD and NHL] showed non- significant change in all Ig levels in pre and post-treatment states, except for IgM in HD. In ALL group, the pre-treatment and remission Ig levels were significantly lower than those of lymphomas and solid Tumors