Prevalence of abnormal cervical cytology among subfertile Saudi women

ABSTRACT

Since cervical cancer is reportedly the seventh most frequent cancer in women in Saudi Arabia and the eighth most frequent cancer among women aged between 15 and 44 years, we wanted to determine the prevalence of abnormal cervical cytology among subfertile women attending the reproductive medicine unit of a tertiary care center in Saudi Arabia. This was a retrospective, cross-sectional, hospital based study. A Pap smear was done for 241 of 493 [48.9%] subfertile women from January 2008 through February 2009. The Pap smear was normal in 166 of 241 patients [67.9%], abnormal in 71 [29.5%], and unsatisfactory for evaluation in 4 [1.7%]. According to the revised Bethesda system, epithelial cell abnormality was found in 7 [2.9%], inflammation in 55 [22.8%], and infection in 9 [3.7%] patients. Epithelial cell abnormalities were further classified as atypical squamous cells of undetermined significance [ASC-US] [n=3, 42.8%], atypical squamous cells of high grade [ASC-H] [n=1, 14.3%], low-grade squamous intraepithelial lesion [LSIL] [n=2, 28.5%], and glandular cell abnormalities [AGS] [n=1, 14.3%]. The high prevalence of abnormal cervical cytology in our subfertile women accentuates the need for screening in patients eligible for in vitro fertilization. In addition, a well-organized screening program for cervical cell abnormalities at the national level should be implemented to allow identification of subfertile women at risk so that potentially life-saving measures can be undertaken early