Changes of lipid metabolism among bilharziatic workers occupationally exposed to carbon disulfide

ABSTRACT

The present study was conducted to evaluate the effect of bilharzia infection on the lipid metabolism among workers exposed to E/ +E/ +E/ +E/ +E/ +CS2. This work included 118 workers exposed to CS2 in Misr Rayon Manufacturing Company, Kafr El-Dawar, 84 of whom were bilharziatic and 91 controls. 46 of whom were bilharziatic. Each subject has been interviewed for his personal, occupational and medical history and history of bilharziasis. Determination of CS2 concentrations in air has been carried out in different departments of the plant. Fasting blood samples were obtained for assessment of fasting blood sugar, GGT activity and serum creatinine levels, the lipid profile including total lipids, cholesterol, triglycerides and phospholipids, the cholesterol and phospholipid content of HDL and LDL and the lipoprotein pattern including the levels of LDL, VLDL and HDL. Bilharziasis, when accompanied by CS2 exposure led to increased GGT activity, cholesterol, triglycerides, phospholipids, LDL and LDLPh levels with decreased HLD and HDLCh levels. These effects were fond to be of the potentiative type of synergism and has been attributed to liver damage. It has been recommended to introduce the assessment of lipid metabolism in the periodic medical examination of these workers