use of Rehydran to prevent acute toxicity of lithium carbonate in rabbits

ABSTRACT

This paper is concerned with the clinical observations on rabbits exposed to a lethal dose of lithium carbonate with or without the treatment of Rehydran solution. Oral administration of lithium alone resulted in significant increases in the blood urea nitrogen, creatinine, uric acid and induced the appearance of proteinuria. It also caused hypernatremia and hypercalcemia. Decreases in blood glucose level and hypokalemia were also detected in lithium treated rabbits. The co-administration of this lethal dose and Rehydran prevented all the previous disturbances and enhanced the urinary excretion of lithium