Study of combination effects of nystatin and clotrimazole with some antibiotics on candida albicans

ABSTRACT

Binary combinations between 2 antifungal agents nystatin and clotrimazole and 4 antibiotics tetracyclines, chloramphenicol, rifampicin and gentamicin were tried using 7 Candida albicans strains isolated from clinical specimen using the checker board method. The best combinations were obtained with nystatin-tetracyclines and clotrimazole- gentamicin. However, synergistic activity between the 2 antifungal agents and these antibiotics was found only at high concentrations of the latter 500 ug - 125 ug/ml, thus limiting its application in vivo