Possibility of reproductive adverse effect of ametryne and/or niclosamide towards male wistar albino rats

ABSTRACT

To study the risk effect of ametryne and niclosamide towards male reproductive system, 10 weeks old male Wistar albino rats have received daily 1/50 LD50 of ametryne [30 mg/kg bw] and niclosamide [84 mg/kg bw], either individually or in combination for 13 weeks. The results showed neither mortality nor gross adverse effects in the treated males throughout the study period. However, body weight and body weight gain were significantly decreased during the last few weeks of ametryne or combined treatment. Moreover, serum testosterone was significantly decreased after ametryne or combined treatment, while it showed an apparent increase after niclosamide treatment. Percentage of motile sperms showed nonsignificant decrease, while percentage of sperms with morphological abnormalities showed significant increase after niclosamide or combined treatment