Reproductive risk assessment in wistar albino rats exposed to ametryne and niclosamids

ABSTRACT

This investigation was designed to assess the reproductive risk of using ametryne and/or niclosamide in the environment. Female and male Wistar albino rats received 1/50 KD50 of ametryne and niclosamide either individually or in combination. Females were treated for 2 weeks prior to mating, throughout mating and pregnancy, to day 21 of lactation, while males were treated for 13 weeks prior to mating. Mating was performed between treated/un-treated females and treated/un-treated males. The results showed neither mortality, clinical nor gross adverse effects in the treated animals. In females treated groups, either ametryne or niclosamide treatment significantly reduced mating and fertility indices. Percentage of post-implantation loss increased under the influence of the combined treatment. In male treated groups, mating, fertility and gestation indices were significantly reduced in the niclosamide-treated group while% treated groups. Number of pups at birth and% of pups/litter that post- implantation loss was survived until weaning were significantly decreased after niclosamide treatment while it was increased after combined treatment. Nevertheless, in female and male treated groups, mating, fertility and gestation indices were significantly decreased after niclosamide or combination treatment