Studies on the induction of stable and prolonged hyperglycemia by subdiabetogenic dose of streptozotocin [STZ]

ABSTRACT

The experiments proved that STZ in doses ranging between 35-62 mg/Kg causes mortality within 24 hours. Determination of sublethal dose proved that 27.5 mg/Kg STZ was safe and induced mild diabetogenic effects. Increasing the diabetogenic efficiency of STZ was conducted by four booster doses amounting to 11.25 mg/Kg/dose administered weekly. The data proved the incidence of hyperglycemia maintained over 45 days from the initial dose. STZ-hyperglycemia was characterized by two phases first grade where mild elevation in blood sugar level was indicated and second grade, accompanied by highly significant hyperglycemia