Modulation of the chemotherapeutic action of some amoebicidal drugs by tin-N-phenylimin chloride

ABSTRACT

Tin-N-phenylimin chloride was tested for its amoebicidal effect on Entamoeba histolytica in vitro and in vivo. Its effects were investigated in combination with metronidazole or bacitracin and compared to the sole effects of each of these drugs or bacitracin zinc. Tin-N-phenylimin chloride or bacitracin zinc was more effective amoebicide than metronidazole or bacitracin on E. histolytica culture. Tin-N-phenylimin chloride synergized the amoebicidal effects of metronidazole or bacitracin to 1.5 and 7.9 times, respectively. Minimal inhibitory and minimal lethal concentrations [MICs, MLCs] were increased in axenic as compared to xenic cultures reaching 1.44-3.5 and 1.05-4.68 times, respectively. The tested drug regimens exhibited a direct amoebicidal effect on E. histolytica in vitro. Clinical effects of these drug regimens were directly proportional to the duration of treatment, reaching a full cure rate five days after treatment. These data indicated that amoebic dysentery cases were advantageously treatable with bacitracin zinc, tin-N-phenylimin chloride or a combination of the latter with metronidazole or bacitracin