Effect of piroxicam, pirprofen and primobolanon the lysosomal acid hydrolases activity and on the total protein and nucleic acids in rat kidney

ABSTRACT

The aim of this work was to study the effect of the administration of piroxicam [Feldene], pirprofen [Rengasil] alone and in combination with the anabolic agent methyl androstenolone acetate [Primobolan] on the total enzymatic activity and extralysosomal release of four selected renal lysosomal enzymes markers; namely, acid phosphatase [ACP], B-N-acetyl-glucosaminidase [B-NAG], B-galactosidase [B-GAL] and alpha- galactosidase [alpha-GAL]. The effect of these drugs on the total protein and the nucleic acids [RNA and DNA] in rat kidney homogenate was also investigated