Response of young and old hypertensive patients with low renin angiotensin aldosterone system to converting enzyme inhibition

ABSTRACT

The present work aimed to study the age related changes of the RAAS and its implication for the most commonly age related disease, essential hypertension. As the RAAS is involved in the pathogenesis of essential hypertension and the ACE inhibitors are used successively for the treatment of hypertensive patients with high and medium RASS, this raised a discussion regarding the efficacy and tolerability of ACE inhibitors in the hypertensive patients with low RAAS reported that the hypertensive patients with low plasma rin values showed no response to ACE inhibitors. Belmin et al [1994] reported that the elderly hypertensive patients with low renin values showed pronounced reductions in blood pressure following treatment with ACE inhibitors. Due to this controversy, this study was done to clarify the responses of the hypertensive patients with low RAAS to ACE inhibitors