Immunological aspects of some vascular thrombotic disorders

ABSTRACT

The study included 30 patients with primary venous thrombosis and 10 patients with primary pulmonary hypertension. The patients were selected after careful clinical evaluation, appropriate investigations and exclusion criteria mentioned in the study. 20 healthy subjects were taken as control group. IgG and IgM anticardiolipin antibodies were measured in all patients as well as control group. It was found that significant increase in IgG and IgM anticardiolipin antibodies in both groups of patients compared to control and in patients with pulmonary embolism compared to those without. Also, more significant elevation to IgG than IgM anticardiolipin antibodies in both groups of patients was found. 6.6% of control group had elevated IgM fraction of anticardiolipin only, while none of them had elevated IgG fraction. Anti cardiolipin antibodies may be involved in the pathogenesis of primary venous thrombosis and primary pulmonary hypertension