Evoluation of some biochemical alterations in neonatal hypoxic ischemic encephalopathy [HIE]

The main objective of this work was to study the evolution of serum L- carnitine and other metabolic derangements that may contribute significantly to the severity of hypoxic ischemic encephalopathy [HIE] including serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], creatinine and electrolyte levels as well as acid-base status. It was conducted on 23 full-term newborns that fulfilled the clinical criteria of hypoxic ischemic encephalopathy in addition to ten healthy full-term newborns of matched weight, gestational and post-natal ages as a control group. It was concluded that L-carnitine may be a useful marker for the severity of HIE. Serum creatinine, AST and ALT levels were significantly increased in all grades of HIE