Effects of prior [lidocaine - morphine] adminstration on cardiov ascular response to tracheal intubation

ABSTRACT

This study was carried out on 30 adult patients classified into three groups, ten patients each. Ten minutes preinduction, they were transtracheally injected with either normal saline, lidocaine 40 mg or a mixture of lidocaine [40 mg] with morphine 1 mg in a volume of 2.5 ml. Heart rate, systolic, diastolic and mean arterial blood pressure were monitored ten minutes before induction and every two minutes for 20 minutes after intubation. There was a significant reduction in heart rate, systolic, diastolic and mean blood pressure in lidocaine group and lidocaine-morphine group compared with the saline group. Also, it was found that heart rate and systolic blood pressure were significantly decreased in both lidocaine and lidocaine- morphine groups compared with the preinduction values