[Evaluation of the association between FokI and BsmI polymorphisms of vitamin D receptor gene and risk of colorectal cancer in Iranian patients referred to Taleghani hospital, Tehran]
Medical Sciences Journal of Islamic Azad University. 2011; 21 (1): 55-60
em Persa
| IMEMR
| ID: emr-109669
ABSTRACT
There are several studies that have identified relationship between VDR gene polymorphisms and colorectal [CRC] or other kinds of cancers, such as breast and prostate cancers. The aim of our study was to evaluate the association of VDR gene polymorphisms, BsmI and FokI, with colorectal cancer risk among Iranian patients. In this case-control study, 110 DNA samples from Iranian CRC patients and 110 samples from healthy Iranian people. Genotyping of BsmI and FokI polymorphisms were performed by PCR-RFLP method. To confirm the RFLP results, 5% of samples were sequenced with direct sequencing method. The frequency of the VDR gene polymorphisms at BsmI and FokI restriction sites in CRC patients and healthy controls was almost similar. Allele distribution in patients and controls was same. There was no statistically significant difference in genotype or allele frequency between CRC patients and control group. VDR FokI and BsmI genotypes are not associated with increased risk of colorectal cancer in Iranian patients. However, these data remain to be confirmed by studies with larger sample size in Iran
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Desoxirribonucleases de Sítio Específico do Tipo II
/
Reação em Cadeia da Polimerase
/
Receptores de Calcitriol
Limite:
Humanos
Idioma:
Persa
Revista:
Med. Sci. J. Islam. Azad Univ.
Ano de publicação:
2011
Similares
MEDLINE
...
LILACS
LIS