Interrelation of t3 and t4 in different conditions represented by the thyroid profile

ABSTRACT

The present study was carried out to determine the picture of T3 and T4, with respect to each other, among male and female population of Rawalpindi/Islamabad. Serum Total 13 and Total T4 levels were determined in 713 patients, using Abbott AxSYM system, based upon MELA [T3] and FPIA [T4] technology. Among the studied male population, no case was seen in which depression of T4 was present among patients with normal T3, as well as having elevated T4 in association with depressed T3. No case, from either gender was seen in which T3 elevation and T4 depression was present. No significant differences were recorded in respective levels of T3 and T4 between genders, in the same groups. With respect to age, it was observed that abnormal thyroid hormone levels are mostly found in people of age 30-40 years. Young and elderly persons are rarely affected. It was also observed that in certain cases the age of male patients was greater, so it can be said that males are affected in later life as compared to females. Thyroid hormone disorder is a commonly occurring disease. Analysis demonstrated that T3 and T4 show a kind of interrelation among themselves in these disorders, since change in one hormone affects the level of the other. Prevalence of these changes is high in females than in males. This study also demonstrated that younger and elderly patients show more normal thyroid hormone levels as compared to the middle aged