Inhibition of anti-inflammatory effect of phenylbutazone by concurrent administration of prednisolone

ABSTRACT

Anti-inflammatory effects of phenylbutazone and prednisolone separately and in combination were studied. In carrageenin-induced rat hind paw edema model, it was observed that concurrent intraperitoneal administration of phenylbutazone [90 mg/kg] and prednisolone [10 mg/kg] produced an anti-inflammatory effect significantly less than that produced by phenylbutazone alone, but was not significantly different from prednisolone alone. A small dose of prednisolone [1 mg/kg] reduced significantly the anti-inflammatory effect of phenylbutazone [10 mg/kg] did not significantly affect the anti-inflammatory effect of prednisolone. In carrageenin-induced granuloma pouch model, concomitant intraperitoneal administration of phenylbutazone [50 mg/kg] and prednisolone [5 mg/kg] once daily for six days produced an anti-inflammatory effect that was significantly less than that produced by any of them receiving phenylbutazone [90 mg/kg] and prednisolone [1 mg/kg] intraperitoneally