Reproductive troubles induced by ivermectin or triclabendazole and their combinations in male rats
Alexandria Journal of Veterinary Sciences [AJVS]. 2010; 31 (1): 35-44
em Inglês
| IMEMR
| ID: emr-110661
ABSTRACT
The present study was carried out to evaluate the effect of administration of ivermectin and / or its interaction with triclabendazole on some reproductive organs weight, epididymal sperm characters and serum testosterone level in mature male rats. Sixty mature male rats were divided equally into 4 groups each of 15 rats. The first group received s.c. ivermectin [0.56 mg/kg. b.wt.], the second group received orally triclabendazole [35mg/kg b.wt.], the third group received ivermectin plus triclabendazole as previously mentioned and the fourth group received saline [control group]. After 31 days from drugs administration, the drugs were repeated to all groups. The obtained results showed that administration of two doses of ivermectin, triclabendazole or both together induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of some reproductive organs weight, changes in semen characters [decrease of sperm count and motility and increase of total sperm abnormalities, as well as a decrease in serum testosterone level. It could be concluded that the most harmful effect on male fertility induced by a coadministration of ivermectin and triclabendazole than giving each drug alone
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Reprodução
/
Benzimidazóis
/
Análise do Sêmen
/
Infertilidade Masculina
Limite:
Animais
Idioma:
Inglês
Revista:
Alex. J. Vet. Sci.
Ano de publicação:
2010
Similares
MEDLINE
...
LILACS
LIS