Efficacy of different antibiotic combinations on uropathogenic multi-drug resistant Escherichia coli
Journal of Drug Research of Egypt. 2010; 31 (1): 41-47
em Inglês
| IMEMR
| ID: emr-110810
ABSTRACT
Using checkerboard titration method as well as time-kill curve technique, the potential synergy of combinations of beta-lactams [ceftazidime and cefepime], aminoglycosides [amikacin, gentamicin, and tobramycin] and fluoroquinolones [ciprofloxacin, levofloxacin, and ofloxacin] were compared against multidrug resistant uropathogenic Escherichia coli isolated from patients with urinary tract infections. In the checkerboard titration studies, none of 21 combinations demonstrated antagonism against 8 strains, five of the 21 combinations showed synergism for more than 40% of the test strains, i.e. ceftazidime tobramycin, ceftazidime levofloxacin, amikacin levofloxacin, amikacin with ofloxacin, and tobramycin with levofloxacin, synergy occurred more often with levofloxacin combined with amikacin [7/8 strains]. Corresponding to the respective fractional inhibitory concentration [FIC] indices, the bactericidal activity determined in combinations of amikacin with ceftazidime or levofloxacin at sub-minimum inhibitory concentrations produced a significant reduction in bacterial count [>/= 2 log 10 cfu/ml] observed within 6 hours of drug administration, at 24 hours, both combinations were bactericidal [reduction in colony count >/= 3 log 10]. Results of this study suggest that amirioglycosides [amikacin and or tobramycin] combination with levofloxacin or ceftazidime could be promising alternatives for the treatment of serious urinary tract infections due to multi drug resistant E. coli
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Infecções Urinárias
/
Farmacorresistência Bacteriana
/
Combinação de Medicamentos
/
Escherichia coli
Limite:
Humanos
Idioma:
Inglês
Revista:
J. Drug Res. Egypt
Ano de publicação:
2010
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