Antinociceptive, anti-inflammatory and acute toxicity effects of Juglans regia L. leaves in mice
IRCMJ-Iranian Red Crescent Medical Journal. 2011; 13 (1): 27-33
em Inglês
| IMEMR
| ID: emr-110846
ABSTRACT
Juglans regia leaves have been used in folk medicine to alleviate inflammatory diseases. This study investigates the antinociceptive, anti-inflammatory and acute toxicity effects of Juglans regia L. leaves in mice. 351 Male and female albino mice were divided into negative [saline], positive [morphine or diclofenac] controls as well as test groups [n=6-8]. The acute [intraperitoneally] toxicity was evaluated for 2 days. Antinociceptive activities were done using hot-plate and writhing tests. Anti-inflammatory effects were studied using xylene induced ear edema and cotton pellet tests. The LD50 values of J. regia aqueous and ethanolic extracts were 5.5 and 3.3 g/kg, respectively. The aqueous [2.87 and 1.64 g/kg] and ethanolic [2.044 and 1.17 g/kg] extracts showed antinociceptive activity in hot-plate test. The pretreatment of naloxone [2 mg/kg, s.c.] did not inhibit the extracts activities. The extracts exhibited antinociceptive activity in writhing test, which were not blocked by naloxone. In xylene test, both extracts showed anti-inflammatory activity in some doses. The extracts showed anti-inflammatory activity against the chronic inflammation. J. regia leaves demonstrated antinociceptive effect through non-opioid receptors and anti-inflammatory effect against acute and chronic inflammation. The extracts of J. regia could be considered as a promising analgesic and anti-inflammatory agents against diseases such as rheumatoid arthritis
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Plantas Medicinais
/
Extratos Vegetais
/
Folhas de Planta
/
Camundongos
/
Anti-Inflamatórios
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. Red Crescent Med. J.
Ano de publicação:
2011
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