Comparison of efficacy and adverse effects of trazodone and paroxetine in major depressive disorder

ABSTRACT

It is an open-label comparative study, conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. The study comprised of two drugs of different groups; total eighty adult patients were enrolled [44 female and 36 male] from the department of psychiatry. Enrolled patients received trazodone 50 mg daily which was gradually increased to 150 mg in divided doses and paroxetine 20 mg daily for a period of 90 days. The results revealed that paroxetine is more effective and has less adverse effects than the trazodone. There was significant improvement in symptoms of sexual disturbance and weight loss of major depressive disorder patients receiving paroxetine