Comparison of the impaired fasting blood glucose in young healthy individuals with diabetic and non-diabetic first degree relatives

To compare the fasting blood glucose [FBG] level in the healthy young individuals with diabetic first degree relatives considered as high risk and non-diabetic first degree relative considered as low risk. Cross-sectional, comparative study. Department of Medicine, Liaquat University of Medical and Health Sciences Hospital, Hyderabad/Jamshoro, from January to November 2008. Individuals aged between 20-40 years were selected and divided into two groups. Group A was considered as high risk included non-diabetic young offspring's of type-2 diabetic parents. Group B was considered as low risk non-diabetic offsprings of non-diabetic family [control group], of same age and gender. Fasting blood glucose levels were measured in each individual. Exclusion criteria were known diabetes and pregnancy. Mean glucose levels were compared using t-test. Proportions of impaired glucose level versus positive family history were compared using chi-square test. Significance was considered at p < 0.05. There were a total of 500 subjects including 250 in each group with equal gender distribution in each group. The mean age was 27.46 +/- 5.71 years. Mean FBG was 87.4 +/- 13.82 mg/dl in group A and 77.7 +/- 15.18 mg/dl in group B [p=0.001]. Twenty five [10%] in group A and five [2%] in group B individuals showed impaired fasting blood glucose [p=0.001]. Impairment of fasting blood glucose was with family history of type-2 Diabetes mellitus in comparison to those without type-2 Diabetes mellitus