study of urinary hydroxyproline [HOP] and alpha antitrypsin in patients with lung cancer and chronic obstructive bronchitis

ABSTRACT

The urinary Hop was measured for 15 patients with bronchial carcinoma, 18 patients with chronic obstructive bronchitis, 15 healthy smokers and 15 healthy non-smokers. There was a significant increase in the level of urinary HOP in patients with chronic obstructive bronchitis. The increase was correlated with the duration of the disease and the degree of air flow limitaion, whereas it did not correlate significantly with the smoking index. Urinary HOP was variably increased in different types of lung cancer with the highest level in small cell carcinoma