Effect of erythrosine on some physiological parameters of the mice

ABSTRACT

The effect of erythrosine on some activity of enzymes in the mice representing glycolytic, gluconeogenic and glycogenolytic pathway and also, liver function enzymes represented by aspartate aminotransferase [AST], alanine aminotransferasc [ALT], acid phosphatase[ACP] and alkaline phosphatase [ALP] and free amino acid were studied. The present results showed that a significant increase in glycolytic enzymes [HK, PK, GPI and PFK], gluconeogenic enzymes, G-6-Pase, acid phosphatase[ACP], alkaline phosphatase[ALP] and glucose, were observed in treated groups, while LDH, glycogen phosphorylase, AST and ALT enzymes activities showed significant reduction. The present results also, showed that significant reduction in glycogen and total protein levels in treated mice as compared to the normal healthy control group. However, the individual amino acids showed variation in their concentrations and percentages of TFAA in tissue of treated mice as compared to control. Aspartic, glutamic, glycine, histidine, arginine, threonine, proline, valine, isolucecine, phenylalanie, lysine and luecine were increased in the tissue, but serine, methionine and cystine, were decreased