Esophageal motility disorders in patients with diabetes mellitus

ABSTRACT

The prevalence of gastrointestinal symptoms seems to be increased in diabetics compared with general population. The aim of this work is to study the esophageal motor abnormalities in diabetic patients to determine whether esophageal motility disorders are related to the symptoms and the clinical status of the patients. The study was conducted on 120 diabetic patients and 20 healthy control divided into-group I 20 healthy controls, group II 60 type I diabetic patients, group III 60 type 2 diabetic patients. They were monitored by laboratory tests-Fundus examination-Abdominal sonography-upper esophagogastric endoscopy-esophageal manometry including lower esophageal sphincter study, esophageal body study, and upper esophageal sphincter study. The data was collected, statistically analyzed using computer program SPSS version nine. There was significant difference between type I and 2 diabetics compared to controls regarding decrease in lower esophageal resting pressure, decrease in peristalsis wave percent, and decrease in proximal, distal body peristaltic amplitude. None significant difference regarding lower esophageal sphincter relaxation percent, residual pressure, proximal body duration, distal body duration and upper esophageal sphincter resting pressure were detected. There was significant difference regarding decrease in peristaltic wave% non transmitted wave% and proximal body amplitude in type I diabetics compared to type 2. Diabetes per se is a significant risk factor for increased incidence of esophageal motility dysfunction in the form of decreased lower esophageal resting pressure, decreased body peristalsis, increased non-transmitted wave percent. Increased double-peak wave percent decreased proximal and distal body amplitude