[Comparison of non-HDL cholestrol level with LDL, cholesterol and other lipids markers level regarding investigation of lipoproteins disorder in hospitalizedpatients in Mazandran Heart Hospital]

ABSTRACT

Considering some restrictions of serum low density lipoprotein [LDL] as a marker for Coronary Artery Disease [CAD] risk factor and also the importance of apo B as a signinificant risk factor for CAD, measurement of non-HDL cholesterol has great value as a risk factor for CAD. Non-HDL cholesterol [total cholesterol minus HDL cholesterol] contains all lipoproteins including apo-lipoproteins. In this study, 200 hospitalized patients [100 men and 100 women] with the diagnosis of CAD, documented by coronary angiography and 100 persons with normal angiography were recruited as case and control groups, respectively. Non-HDL cholesterol non-HDL-c was compared with LDL- cholesterol as a risk factor for CAD. Measured levels of triglyceride, total cholesterol, lipoprotein atherogenic a [Lpa] and non-HDL-c were significantly higher than those in control group. HDL level was lower in patients group. Correlation analysis showed that non-HDL-c [and not LDL cholesterol] had a higher reverse correlation triglyceride level. Measurement of non-HDL-c could be a good marker in atherogenic lipoproteins. Furthermore, due to potential power of its other atherogenic lipoproteins, it cannot be measured by LDL alone