Paclitaxel and cisplatin for patients with advanced gastric cancer
Bulletin of Alexandria Faculty of Medicine. 2007; 43 (3): 575-579
em Inglês
| IMEMR
| ID: emr-112194
ABSTRACT
Because of the unsatisfactory treatment results with 5-fluorouracil-based palliative combination chemotherapy for advanced gastric cancer, we conducted this study to evaluate the efficacy and safety of a combination of pacitaxel and cisplatin in patients with previously untreated metastatic or unresectable gastric adenocarcinoma. Twenty-five of 27 patients that were entered into this study between January 2003 and August 2005 received chemotherapy. Paclitaxel was administerd at a dose of 175 mg/m2 as a 3-hour intravenous infusion and Cisplatin at 75 mg/m2 as an intravenous infusion on day 1 every 3 weeks. Nine patients [36%] achieved a partial response, 7 patients [28%] a stable disease, and 5 patients [20%] progressed. The overall response rate was 36% [95% concidence interval [CI], 17 to 55%]. The median duration of the response was 7.8 months [95% CI, 6.6 to 9.0 months]. The median time to progression was 7.4 months [95% CI, 5.3 to 9.5 months], and median overall survival was 13.3 months [95% CI, 10.8 to 15.9 months]. The major toxicity was hematological, with grade 3 and 4 neutropenia in 10% [10/106] of the total cycles. The non-hematologic toxicity was mild, and grade 3 emesis was observed in 2 patients [8%]. The results suggest that a combination of paclitaxel and cisplatin is an effective and well-tolerated regimen for patients treated for advanced gastric adenocarcinoma
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Cisplatino
/
Paclitaxel
/
Quimioterapia Combinada
/
Metástase Neoplásica
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Bull. Alex. Fac. Med.
Ano de publicação:
2007
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