Chemical and biological investigations of the roots of sonchus oleraceus L. growing in Egypt

Phytochemical study of the roots of Sonchus oleraceus L [Astraceae] growing in Egypt, afforded loliolide 1 for the first time from the genus Sonchus in addition to 1 5-O-beta-glucopyranosyl-11beta, 13-dihydrourospermal A 2, ursolic acid 3, lupeol 4, and beta-sitosterol-3-O- beta-glucopyranoside 5 for the first time from the species. The biological evaluation of the isolated compounds showed cytotoxic activity of 1 and 2 against L5187Y cell line, while compound 2 showed activity against PCS 3 cell line. In addition to antibacterial activity of compounds 1 and 2 against S. aureus, B. subtilis, E. Coli, and N. gonorrhoea. The structures of the isolated compounds were elucidated using 1D [[1]H and [13]C], 2D [H-H COSY, HMQC and HMBC] NMR and MS spectroscopic data