H. pylori stool antigen [HpSA]: anew simple test for detection of infection

ABSTRACT

Thirty patient with duodenal ulcer who underwent upper gastrointestinal endoscopy were selected for assessment of HpSA immunoassay test in detection of H.pylori infection [16 male [53.3%], 14 female [46.7%] mean age 42 +/- 1 year]. Patients with previous surgery, use of antibiotics, proton pump inhibitors or any compound containing bithmus up to one month before study were excluded. All patients were assessed clinically, upper endoscopy and biopsies from antrum were taken for urease test and culture, blood samples were analyzed for H.pylori IgG antibodies by ELIZA. Stool samples were taken for HpSA immunoassay using [Medridian-Diagnostic-inc-cinncina oH immunoassay]. From the 27 patients diagnosed by culture as H.pylori positive, urease test detected 96%, IgG antibodies were positive in 93% and HpSA immunoassay detected 70%. The sensitivity and the specificity of HpSA test in comparison to culture were 70.4% and 100% respectively and to urease test were 73.1% and 100% respectively. HpSA immunoassay test is simple rapid non invasive, specific test for detection of H.pylori infection