Tissue culture for studying the effect of mechanical pressure on cartilage

ABSTRACT

Tissue culture for cartilagenous plates was done to study the effect of pressure from different directions unmodified by the presence of other tissues such as muscles, nerves and blood vessels. The chondrocytes lost their orientation and became parallel with the long axes of the pressure lines. The ground substance gradually disappeared and replaced by collagen fibrils that became parallel with the long axes of the packed and elongated cartilagenous cells